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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10359 | AR antagonist 1 | Androgen Receptor , Ligand for E3 Ligase , Ligands for Target Protein for PROTAC | |
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266. | |||
T2110 | (+)-JQ-1 | JQ1 | Epigenetic Reader Domain , Autophagy , Ligands for Target Protein for PROTAC |
(+)-JQ-1 (JQ1) is a BET bromine domain inhibitor that inhibits BRD4 (1/2) (IC50=77/33 nM) with specificity and reversibility. (+)-JQ-1 induces cell autophagy and inhibits cell proliferation. | |||
T5480 | BI-4464 | FAK , Ligands for Target Protein for PROTAC | |
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC | |||
T12186 | Navitoclax-piperazine | ABT-263-piperazine | BCL , Ligands for Target Protein for PROTAC |
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL). | |||
T1835 | Ibrutinib | PCI-32765 | Tyrosine Kinases , Src , BTK , Ligands for Target Protein for PROTAC |
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation. | |||
T39910 | Desmorpholinyl Navitoclax-NH-Me | Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me | BCL |
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2]. | |||
T19301 | DUPA | N,N''-Carbonylbis[L-glutamic acid],(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid | Others , Ligands for Target Protein for PROTAC |
DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. | |||
T2066 | Quizartinib | AC220 | Apoptosis , FLT , Autophagy , Ligands for Target Protein for PROTAC |
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. | |||
T15125 | Diethylene Glycol Monobenzyl Ether | Others | |
Diethylene Glycol Monobenzyl Ether is a PEG-based linker, specifically designed for the synthesis of PROTACs[1]. It serves as a versatile chemical compound, enabling the formation of PROTAC molecules by connecting target... | |||
T17345 | 7-Octynoic acid | Others | |
7-Octynoic acid (compound 42) serves as a PROTAC linker for synthesizing various PROTACs, which are composed of two distinct ligands joined by this linker. One ligand interacts with an E3 ubiquitin ligase, while the othe... | |||
T18542 | Phthalimide-PEG3-C2-OTs | Others | |
Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC linker composed of PEGs. It is utilized in the synthesis of various PROTACs, which involve the connection of two distinct ligands through a linker. One ligand is specific ... | |||
T83953 | Pomalidomide 4'-PEG5-amine | ||
Pomalidomide 4'-PEG5-amine, a cereblon ligand designed for PROTAC research and development, features an integrated E3 ligase ligand and a PEG5 linker ending in an amine for easy conjugation to target protein ligands. It ... | |||
T83954 | VH 032 amide-alkylC7-acid | (S,R,S)-AHPC-amido-C7-acid | |
VH 032 amide-alkylC7-acid is a specialized compound designed for PROTAC research and development, serving as a functionalized von-Hippel-Lindau (VHL) protein ligand. It combines an E3 ligase ligand with an alkylC7 linker... |